R01 GM022172/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2001	1
2005	1
2006	2
2007	3
2008	3
2009	2
2010	6
2011	3
2012	4
2013	5
2014	3
2016	6
2017	4
2018	3
2024	0

1

Structure and mechanism of assembly line polyketide synthases.

Robbins T, Liu YC, Cane DE, Khosla C. Robbins T, et al. Curr Opin Struct Biol. 2016 Dec;41:10-18. doi: 10.1016/j.sbi.2016.05.009. Epub 2016 Jun 5. Curr Opin Struct Biol. 2016. PMID: 27266330 Free PMC article. Review.

2

Assembly line polyketide synthases: mechanistic insights and unsolved problems.

Khosla C, Herschlag D, Cane DE, Walsh CT. Khosla C, et al. Biochemistry. 2014 May 13;53(18):2875-83. doi: 10.1021/bi500290t. Epub 2014 May 1. Biochemistry. 2014. PMID: 24779441 Free PMC article. Review.

3

Revisiting the modularity of modular polyketide synthases.

Khosla C, Kapur S, Cane DE. Khosla C, et al. Curr Opin Chem Biol. 2009 Apr;13(2):135-43. doi: 10.1016/j.cbpa.2008.12.018. Epub 2009 Feb 11. Curr Opin Chem Biol. 2009. PMID: 19217343 Free PMC article. Review.

4

Programming of erythromycin biosynthesis by a modular polyketide synthase.

Cane DE. Cane DE. J Biol Chem. 2010 Sep 3;285(36):27517-23. doi: 10.1074/jbc.R110.144618. Epub 2010 Jun 3. J Biol Chem. 2010. PMID: 20522551 Free PMC article. Review. No abstract available.

5

Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases.

You YO, Khosla C, Cane DE. You YO, et al. J Am Chem Soc. 2013 May 22;135(20):7406-9. doi: 10.1021/ja4014776. Epub 2013 May 13. J Am Chem Soc. 2013. PMID: 23659177 Free PMC article.

6

Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.

Ostrowski MP, Cane DE, Khosla C. Ostrowski MP, et al. J Antibiot (Tokyo). 2016 Jul;69(7):507-10. doi: 10.1038/ja.2016.41. Epub 2016 Apr 27. J Antibiot (Tokyo). 2016. PMID: 27118242 Free PMC article.

7

pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism.

Xie X, Cane DE. Xie X, et al. Org Biomol Chem. 2018 Dec 5;16(47):9165-9170. doi: 10.1039/c8ob02637h. Org Biomol Chem. 2018. PMID: 30457629 Free PMC article.

8

Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase.

Wong FT, Jin X, Mathews II, Cane DE, Khosla C. Wong FT, et al. Biochemistry. 2011 Aug 2;50(30):6539-48. doi: 10.1021/bi200632j. Epub 2011 Jul 5. Biochemistry. 2011. PMID: 21707057 Free PMC article.

9

Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.

Xie X, Cane DE. Xie X, et al. Biochemistry. 2018 Jun 5;57(22):3126-3129. doi: 10.1021/acs.biochem.7b01253. Epub 2018 Jan 5. Biochemistry. 2018. PMID: 29293329 Free PMC article.

10

Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase.

Dunn BJ, Cane DE, Khosla C. Dunn BJ, et al. Biochemistry. 2013 Mar 19;52(11):1839-41. doi: 10.1021/bi400185v. Epub 2013 Mar 5. Biochemistry. 2013. PMID: 23452124 Free PMC article.

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