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Epigenetic dosage identifies two major and functionally distinct β cell subtypes.
Dror E, Fagnocchi L, Wegert V, Apostle S, Grimaldi B, Gruber T, Panzeri I, Heyne S, Höffler KD, Kreiner V, Ching R, Tsai-Hsiu Lu T, Semwal A, Johnson B, Senapati P, Lempradl A, Schones D, Imhof A, Shen H, Pospisilik JA. Dror E, et al. Cell Metab. 2023 May 2;35(5):821-836.e7. doi: 10.1016/j.cmet.2023.03.008. Epub 2023 Mar 21. Cell Metab. 2023. PMID: 36948185 Free PMC article.
Developmental priming of cancer susceptibility.
Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Chih-Hsiang Y, Bergsma A, Drougard A, Dror E; PERMUTE; Chandler D, Schramek D, Triche TJ Jr, Pospisilik JA. Panzeri I, et al. bioRxiv [Preprint]. 2023 Sep 15:2023.09.12.557446. doi: 10.1101/2023.09.12.557446. bioRxiv. 2023. PMID: 37745326 Free PMC article. Preprint.
Independent phenotypic plasticity axes define distinct obesity sub-types.
Yang CH, Fagnocchi L, Apostle S, Wegert V, Casaní-Galdón S, Landgraf K, Panzeri I, Dror E, Heyne S, Wörpel T, Chandler DP, Lu D, Yang T, Gibbons E, Guerreiro R, Bras J, Thomasen M, Grunnet LG, Vaag AA, Gillberg L, Grundberg E, Conesa A, Körner A; PERMUTE; Pospisilik JA. Yang CH, et al. Nat Metab. 2022 Sep;4(9):1150-1165. doi: 10.1038/s42255-022-00629-2. Epub 2022 Sep 12. Nat Metab. 2022. PMID: 36097183 Free PMC article.
An acute microglial metabolic response controls metabolism and improves memory.
Drougard A, Ma EH, Wegert V, Sheldon R, Panzeri I, Vatsa N, Apostle S, Fagnocchi L, Schaf J, Gossens K, Völker J, Pang S, Bremser A, Dror E, Giacona F, Sagar, Henderson MX, Prinz M, Jones RG, Pospisilik JA. Drougard A, et al. bioRxiv [Preprint]. 2024 Apr 25:2023.04.03.535373. doi: 10.1101/2023.04.03.535373. bioRxiv. 2024. PMID: 37066282 Free PMC article. Preprint.
Chronic obesity does not alter cancer survival in Tp53 R270H/+ mice.
Panzeri I, Madaj Z, Fagnocchi L, Apostle S, Tompkins M, Hostetter G, Pospisilik JA. Panzeri I, et al. bioRxiv [Preprint]. 2024 Oct 16:2024.10.14.618190. doi: 10.1101/2024.10.14.618190. bioRxiv. 2024. PMID: 39463991 Free PMC article. Preprint.