R01 HL036709/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2004	1
2007	1
2008	4
2010	1
2011	1
2012	2
2013	2
2024	0

1

Ezetimibe blocks internalization of the NPC1L1/cholesterol complex.

Chang TY, Chang C. Chang TY, et al. Cell Metab. 2008 Jun;7(6):469-71. doi: 10.1016/j.cmet.2008.05.001. Cell Metab. 2008. PMID: 18522826 Free article. Review.

2

A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth.

Lu M, Hu XH, Li Q, Xiong Y, Hu GJ, Xu JJ, Zhao XN, Wei XX, Chang CC, Liu YK, Nan FJ, Li J, Chang TY, Song BL, Li BL. Lu M, et al. J Mol Cell Biol. 2013 Dec;5(6):404-15. doi: 10.1093/jmcb/mjt039. Epub 2013 Oct 26. J Mol Cell Biol. 2013. PMID: 24163426 Free PMC article.

3

Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.

Rogers MA, Liu J, Kushnir MM, Bryleva E, Rockwood AL, Meikle AW, Shapiro D, Vaisman BL, Remaley AT, Chang CCY, Chang TY. Rogers MA, et al. J Biol Chem. 2012 May 18;287(21):17483-17492. doi: 10.1074/jbc.M111.331306. Epub 2012 Apr 2. J Biol Chem. 2012. PMID: 22474282 Free PMC article.

4

RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform.

Chen J, Zhao XN, Yang L, Hu GJ, Lu M, Xiong Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL. Chen J, et al. Cell Res. 2008 Sep;18(9):921-36. doi: 10.1038/cr.2008.66. Cell Res. 2008. PMID: 18542101 Free PMC article.

5

The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins.

Poirier S, Mayer G, Murphy SR, Garver WS, Chang TY, Schu P, Seidah NG. Poirier S, et al. Traffic. 2013 Apr;14(4):458-69. doi: 10.1111/tra.12046. Epub 2013 Feb 20. Traffic. 2013. PMID: 23350547 Free PMC article.

6

Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain.

Ohgami N, Ko DC, Thomas M, Scott MP, Chang CC, Chang TY. Ohgami N, et al. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12473-8. doi: 10.1073/pnas.0405255101. Epub 2004 Aug 16. Proc Natl Acad Sci U S A. 2004. PMID: 15314240 Free PMC article.

7

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex.

Urano Y, Watanabe H, Murphy SR, Shibuya Y, Geng Y, Peden AA, Chang CC, Chang TY. Urano Y, et al. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16513-8. doi: 10.1073/pnas.0807450105. Epub 2008 Oct 22. Proc Natl Acad Sci U S A. 2008. PMID: 18946045 Free PMC article.

8

Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.

Reid PC, Lin S, Vanier MT, Ohno-Iwashita Y, Harwood HJ Jr, Hickey WF, Chang CC, Chang TY. Reid PC, et al. J Neurosci Methods. 2008 Feb 15;168(1):15-25. doi: 10.1016/j.jneumeth.2007.09.002. Epub 2007 Sep 12. J Neurosci Methods. 2008. PMID: 17949821 Free PMC article.

9

A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations.

Maue RA, Burgess RW, Wang B, Wooley CM, Seburn KL, Vanier MT, Rogers MA, Chang CC, Chang TY, Harris BT, Graber DJ, Penatti CA, Porter DM, Szwergold BS, Henderson LP, Totenhagen JW, Trouard TP, Borbon IA, Erickson RP. Maue RA, et al. Hum Mol Genet. 2012 Feb 15;21(4):730-50. doi: 10.1093/hmg/ddr505. Epub 2011 Nov 2. Hum Mol Genet. 2012. PMID: 22048958 Free PMC article.

10

Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity.

Sakashita N, Chang CC, Lei X, Fujiwara Y, Takeya M, Chang TY. Sakashita N, et al. J Lipid Res. 2010 Jun;51(6):1263-72. doi: 10.1194/jlr.M900288. J Lipid Res. 2010. PMID: 20460577 Free PMC article.

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