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Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses.
Qiu L, Huang D, Chen CY, Wang R, Shen L, Shen Y, Hunt R, Estep J, Haynes BF, Jacobs WR Jr, Letvin N, Du G, Chen ZW. Qiu L, et al. J Infect Dis. 2008 Nov 15;198(10):1514-9. doi: 10.1086/592448. J Infect Dis. 2008. PMID: 18811584 Free PMC article.