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Page 1
Remodeling oncogenic transcriptomes by small molecules targeting NONO.
Kathman SG, Koo SJ, Lindsey GL, Her HL, Blue SM, Li H, Jaensch S, Remsberg JR, Ahn K, Yeo GW, Ghosh B, Cravatt BF. Kathman SG, et al. Nat Chem Biol. 2023 Jul;19(7):825-836. doi: 10.1038/s41589-023-01270-0. Epub 2023 Mar 2. Nat Chem Biol. 2023. PMID: 36864190 Free PMC article.
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment.
Trujillo CA, Rice ES, Schaefer NK, Chaim IA, Wheeler EC, Madrigal AA, Buchanan J, Preissl S, Wang A, Negraes PD, Szeto RA, Herai RH, Huseynov A, Ferraz MSA, Borges FS, Kihara AH, Byrne A, Marin M, Vollmers C, Brooks AN, Lautz JD, Semendeferi K, Shapiro B, Yeo GW, Smith SEP, Green RE, Muotri AR. Trujillo CA, et al. Science. 2021 Feb 12;371(6530):eaax2537. doi: 10.1126/science.aax2537. Science. 2021. PMID: 33574182 Free PMC article.
A multi-scale map of cell structure fusing protein images and interactions.
Qin Y, Huttlin EL, Winsnes CF, Gosztyla ML, Wacheul L, Kelly MR, Blue SM, Zheng F, Chen M, Schaffer LV, Licon K, Bäckström A, Vaites LP, Lee JJ, Ouyang W, Liu SN, Zhang T, Silva E, Park J, Pitea A, Kreisberg JF, Gygi SP, Ma J, Harper JW, Yeo GW, Lafontaine DLJ, Lundberg E, Ideker T. Qin Y, et al. Nature. 2021 Dec;600(7889):536-542. doi: 10.1038/s41586-021-04115-9. Epub 2021 Nov 24. Nature. 2021. PMID: 34819669 Free PMC article.
In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.
Vujovic A, de Rooij L, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. Vujovic A, et al. Blood Cancer Discov. 2023 May 1;4(3):180-207. doi: 10.1158/2643-3230.BCD-22-0086. Blood Cancer Discov. 2023. PMID: 36763002 Free PMC article.
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. Koga T, et al. Nat Commun. 2020 Jan 28;11(1):550. doi: 10.1038/s41467-020-14312-1. Nat Commun. 2020. PMID: 31992716 Free PMC article.