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Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Kathiriya JJ, et al. Nat Cell Biol. 2022 Jan;24(1):10-23. doi: 10.1038/s41556-021-00809-4. Epub 2021 Dec 30. Nat Cell Biol. 2022. PMID: 34969962 Free PMC article.
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. Reyes NS, et al. Science. 2022 Oct 14;378(6616):192-201. doi: 10.1126/science.abf3326. Epub 2022 Oct 13. Science. 2022. PMID: 36227993 Free PMC article.
An inflammatory switch for stem cell plasticity.
Kathiriya JJ, Peng T. Kathiriya JJ, et al. Nat Cell Biol. 2021 Sep;23(9):928-929. doi: 10.1038/s41556-021-00752-4. Nat Cell Biol. 2021. PMID: 34475536 Free PMC article.
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Wang C, et al. J Clin Invest. 2018 Oct 1;128(10):4343-4358. doi: 10.1172/JCI99435. Epub 2018 Jul 12. J Clin Invest. 2018. PMID: 29999500 Free PMC article.