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Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.
Marchiano S, Nakamura K, Reinecke H, Neidig L, Lai M, Kadota S, Perbellini F, Yang X, Klaiman JM, Blakely LP, Karbassi E, Fields PA, Fenix AM, Beussman KM, Jayabalu A, Kalucki FA, Potter JC, Futakuchi-Tsuchida A, Weber GJ, Dupras S, Tsuchida H, Pabon L, Wang L, Knollmann BC, Kattman S, Thies RS, Sniadecki N, MacLellan WR, Bertero A, Murry CE. Marchiano S, et al. Cell Stem Cell. 2023 Apr 6;30(4):396-414.e9. doi: 10.1016/j.stem.2023.03.010. Cell Stem Cell. 2023. PMID: 37028405 Free PMC article.
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques.
Lin Y, Sato N, Hong S, Nakamura K, Ferrante EA, Yu ZX, Chen MY, Nakamura DS, Yang X, Clevenger RR, Hunt TJ, Taylor JL, Jeffries KR, Keeran KJ, Neidig LE, Mehta A, Schwartzbeck R, Yu SJ, Kelly C, Navarengom K, Takeda K, Adler SS, Choyke PL, Zou J, Murry CE, Boehm M, Dunbar CE. Lin Y, et al. Cell Stem Cell. 2024 Jul 5;31(7):974-988.e5. doi: 10.1016/j.stem.2024.05.005. Epub 2024 Jun 5. Cell Stem Cell. 2024. PMID: 38843830
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.
Marchiano S, Nakamura K, Reinecke H, Neidig L, Lai M, Kadota S, Perbellini F, Yang X, Klaiman JM, Blakely LP, Karbassi E, Fields PA, Fenix AM, Beussman KM, Jayabalu A, Kalucki FA, Potter JC, Futakuchi-Tsuchida A, Weber GJ, Dupras S, Tsuchida H, Pabon L, Wang L, Knollmann BC, Kattman S, Thies RS, Sniadecki N, MacLellan WR, Bertero A, Murry CE. Marchiano S, et al. Cell Stem Cell. 2023 May 4;30(5):741. doi: 10.1016/j.stem.2023.04.010. Cell Stem Cell. 2023. PMID: 37146587 Free PMC article. No abstract available.
Lessons learnt, and still to learn, in first in human stem cell trials.
Barker RA, Carpenter M, Jamieson CHM, Murry CE, Pellegrini G, Rao RC, Song J. Barker RA, et al. Stem Cell Reports. 2023 Aug 8;18(8):1599-1609. doi: 10.1016/j.stemcr.2022.11.019. Epub 2022 Dec 22. Stem Cell Reports. 2023. PMID: 36563687 Free PMC article. Review.
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes.
Friedman CE, Fayer S, Pendyala S, Chien WM, Loiben A, Tran L, Chao LS, McKinstry A, Ahmed D, Farris SD, Stempien-Otero A, Jonlin EC, Murry CE, Starita LM, Fowler DM, Yang KC. Friedman CE, et al. Circ Genom Precis Med. 2024 Apr;17(2):e004377. doi: 10.1161/CIRCGEN.123.004377. Epub 2024 Feb 16. Circ Genom Precis Med. 2024. PMID: 38362799
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