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Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex.
Uzquiano A, Kedaigle AJ, Pigoni M, Paulsen B, Adiconis X, Kim K, Faits T, Nagaraja S, Antón-Bolaños N, Gerhardinger C, Tucewicz A, Murray E, Jin X, Buenrostro J, Chen F, Velasco S, Regev A, Levin JZ, Arlotta P. Uzquiano A, et al. Cell. 2022 Sep 29;185(20):3770-3788.e27. doi: 10.1016/j.cell.2022.09.010. Cell. 2022. PMID: 36179669 Free PMC article.
Brain Chimeroids reveal individual susceptibility to neurotoxic triggers.
Antón-Bolaños N, Faravelli I, Faits T, Andreadis S, Kastli R, Trattaro S, Adiconis X, Wei A, Sampath Kumar A, Di Bella DJ, Tegtmeyer M, Nehme R, Levin JZ, Regev A, Arlotta P. Antón-Bolaños N, et al. Nature. 2024 Jul;631(8019):142-149. doi: 10.1038/s41586-024-07578-8. Epub 2024 Jun 26. Nature. 2024. PMID: 38926573
Autism genes converge on asynchronous development of shared neuron classes.
Paulsen B, Velasco S, Kedaigle AJ, Pigoni M, Quadrato G, Deo AJ, Adiconis X, Uzquiano A, Sartore R, Yang SM, Simmons SK, Symvoulidis P, Kim K, Tsafou K, Podury A, Abbate C, Tucewicz A, Smith SN, Albanese A, Barrett L, Sanjana NE, Shi X, Chung K, Lage K, Boyden ES, Regev A, Levin JZ, Arlotta P. Paulsen B, et al. Nature. 2022 Feb;602(7896):268-273. doi: 10.1038/s41586-021-04358-6. Epub 2022 Feb 2. Nature. 2022. PMID: 35110736 Free PMC article.