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Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
Dichiara M, Ambrosio FA, Lee SM, Ruiz-Cantero MC, Lombino J, Coricello A, Costa G, Shah D, Costanzo G, Pasquinucci L, Son KN, Cosentino G, González-Cano R, Marrazzo A, Aakalu VK, Cobos EJ, Alcaro S, Amata E. Dichiara M, et al. J Med Chem. 2023 Aug 24;66(16):11447-11463. doi: 10.1021/acs.jmedchem.3c00959. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535861 Free PMC article.
Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons.
Hippman RS, Snead AM, Petros ZA, Korkmaz-Vaisys MA, Patel S, Sotelo D, Dobria A, Salkovski M, Nguyen TTA, Linares R, Cologna SM, Gowrishankar S, Aldrich LN. Hippman RS, et al. ACS Chem Neurosci. 2023 Dec 20;14(24):4363-4382. doi: 10.1021/acschemneuro.3c00573. Epub 2023 Dec 9. ACS Chem Neurosci. 2023. PMID: 38069806 Free PMC article.
11 results