Abstract
We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 microM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aerobiosis
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Anaerobiosis
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Animals
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Antitrichomonal Agents / pharmacology*
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Cations / pharmacology*
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DNA, Protozoan / drug effects
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DNA, Protozoan / metabolism
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Drug Resistance, Fungal
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Magnetic Resonance Spectroscopy
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Metronidazole / pharmacology
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Nitroimidazoles / pharmacology
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Trichomonas vaginalis / drug effects*
Substances
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Antitrichomonal Agents
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Cations
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DNA, Protozoan
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Nitroimidazoles
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Metronidazole