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Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
Neuron. 2023 Nov 15;111(22):3619-3633.e8. doi: 10.1016/j.neuron.2023.08.012. Epub 2023 Sep 8.
Neuron. 2023.
PMID: 37689059
Free PMC article.
Exercise hormone irisin is a critical regulator of cognitive function.
Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD.
Islam MR, et al.
Nat Metab. 2021 Aug;3(8):1058-1070. doi: 10.1038/s42255-021-00438-z. Epub 2021 Aug 20.
Nat Metab. 2021.
PMID: 34417591
Free PMC article.
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