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Increased activity of IRE1 improves the clinical presentation of EAE.
Bracchi-Ricard V, Nguyen K, Ricci D, Gaudette B, Henao-Mejia J, Brambilla R, Martynyuk T, Gidalevitz T, Allman D, Bethea JR, Argon Y. Bracchi-Ricard V, et al. FASEB J. 2023 Dec;37(12):e23283. doi: 10.1096/fj.202300769RR. FASEB J. 2023. PMID: 37983957 Free PMC article.
An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation.
Ricci D, Tutton S, Marrocco I, Ying M, Blumenthal D, Eletto D, Vargas J, Boyle S, Fazelinia H, Qian L, Suresh K, Taylor D, Paton JC, Paton AW, Tang CA, Hu CA, Radhakrishnan R, Gidalevitz T, Argon Y. Ricci D, et al. J Biol Chem. 2021 Jan-Jun;296:100781. doi: 10.1016/j.jbc.2021.100781. Epub 2021 May 14. J Biol Chem. 2021. PMID: 34000298 Free PMC article.