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Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia.
Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens YA, Wang X, Li L, Liu CC, Chen K, Zhu Y, Ikezu TC, Li Z, Meneses AD, Jin Y, Knight JA, Chen Y, Bastea L, Linares C, Sonustun B, Job L, Smith ML, Xie M, Liu YU, Umpierre AD, Haruwaka K, Quicksall ZS, Storz P, Asmann YW, Wu LJ, Bu G. Zhao N, et al. J Exp Med. 2022 Dec 5;219(12):e20212479. doi: 10.1084/jem.20212479. Epub 2022 Sep 15. J Exp Med. 2022. PMID: 36107206 Free PMC article.
Microglial TREM2 in amyotrophic lateral sclerosis.
Xie M, Zhao S, Bosco DB, Nguyen A, Wu LJ. Xie M, et al. Dev Neurobiol. 2022 Jan;82(1):125-137. doi: 10.1002/dneu.22864. Epub 2021 Dec 18. Dev Neurobiol. 2022. PMID: 34874625 Free PMC article. Review.
The Emerging Role of Microglia in Neuromyelitis Optica.
Chen T, Bosco DB, Ying Y, Tian DS, Wu LJ. Chen T, et al. Front Immunol. 2021 Feb 19;12:616301. doi: 10.3389/fimmu.2021.616301. eCollection 2021. Front Immunol. 2021. PMID: 33679755 Free PMC article. Review.
TREM2 mediates MHCII-associated CD4+ T cell response against gliomas.
Zheng J, Wang L, Zhao S, Zhang W, Chang Y, Dheer A, Gao S, Xu S, Ayasoufi K, Al-Kharboosh R, Xie M, Johnson AJ, Dong H, Quiñones-Hinojosa A, Wu LJ. Zheng J, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.05.535697. doi: 10.1101/2023.04.05.535697. bioRxiv. 2023. Update in: Neuro Oncol. 2024 May 3;26(5):811-825. doi: 10.1093/neuonc/noad214. PMID: 37066234 Free PMC article. Updated. Preprint.