Abstract
Genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberculosis isolates from the Western Cape Province of South Africa showed that drug resistance is widespread and recently transmitted. Multidrug-resistant (MDR) isolates comprise 40% of this collection, and a large pool of isoniazid monoresistance may be a future source of MDR tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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DNA Primers
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Drug Resistance, Bacterial / genetics*
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Drug Resistance, Multiple / genetics*
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Genotype
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Geography
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Humans
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification*
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Phenotype
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Rural Population
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South Africa / epidemiology
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Tuberculosis / diagnosis*
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Tuberculosis / epidemiology
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Tuberculosis / transmission