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Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice.
Cell Death Dis. 2019 Oct 3;10(10):754. doi: 10.1038/s41419-019-1985-3.
Cell Death Dis. 2019.
PMID: 31582730
Free PMC article.
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health.
Zhang C, Gordon MD, Joseph KM, Diaz-Hernandez ME, Drissi H, Illien-Jünger S.
Zhang C, et al.
JOR Spine. 2023 Dec 4;7(1):e1306. doi: 10.1002/jsp2.1306. eCollection 2024 Mar.
JOR Spine. 2023.
PMID: 38222816
Free PMC article.
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PHLPP1 deficiency protects against age-related intervertebral disc degeneration.
Zhang C, Joseph KM, Khan NM, Diaz-Hernandez ME, Drissi H, Illien-Junger S.
Zhang C, et al.
JOR Spine. 2022 Sep 27;5(4):e1224. doi: 10.1002/jsp2.1224. eCollection 2022 Dec.
JOR Spine. 2022.
PMID: 36601379
Free PMC article.
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