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Combinatorial approaches targeting the EGFR family and c-Met in SCCHN.
Wang D, Lu Y, Nannapaneni S, Griffith CC, Steuer C, Qian G, Wang X, Chen Z, Patel M, El-Deiry M, Shin DM, He X, Chen ZG, Saba NF. Wang D, et al. Oral Oncol. 2021 Jan;112:105074. doi: 10.1016/j.oraloncology.2020.105074. Epub 2020 Nov 2. Oral Oncol. 2021. PMID: 33142224
Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.
Zhou W, Sun W, Yung MMH, Dai S, Cai Y, Chen CW, Meng Y, Lee JB, Braisted JC, Xu Y, Southall NT, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung ANY, Ngan HYS, Liu SS, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan DW, Zheng W, Zhu W. Zhou W, et al. Oncogene. 2018 Jul;37(29):3981-3997. doi: 10.1038/s41388-018-0238-8. Epub 2018 Apr 17. Oncogene. 2018. PMID: 29662190 Free PMC article.
HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models.
Wang D, Qian G, Zhang H, Magliocca KR, Nannapaneni S, Amin AR, Rossi M, Patel M, El-Deiry M, Wadsworth JT, Chen Z, Khuri FR, Shin DM, Saba NF, Chen ZG. Wang D, et al. Clin Cancer Res. 2017 Feb 1;23(3):677-686. doi: 10.1158/1078-0432.CCR-16-0558. Epub 2016 Jun 29. Clin Cancer Res. 2017. PMID: 27358485 Free PMC article.