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Direct inhibition of RAS: Quest for the Holy Grail?
Spencer-Smith R, O'Bryan JP. Spencer-Smith R, et al. Semin Cancer Biol. 2019 Feb;54:138-148. doi: 10.1016/j.semcancer.2017.12.005. Epub 2017 Dec 14. Semin Cancer Biol. 2019. PMID: 29248537 Free PMC article. Review.
Inhibition of RAS function through targeting an allosteric regulatory site.
Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP. Spencer-Smith R, et al. Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231. Epub 2016 Nov 7. Nat Chem Biol. 2017. PMID: 27820802 Free PMC article.