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VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms.
Zhang K, Zakeri A, Alban T, Dong J, Ta HM, Zalavadia AH, Branicky A, Zhao H, Juric I, Husich H, Parthasarathy PB, Rupani A, Drazba JA, Chakraborty AA, Ching-Cheng Huang S, Chan T, Avril S, Wang LL. Zhang K, et al. Cell Rep. 2024 Jan 23;43(1):113661. doi: 10.1016/j.celrep.2023.113661. Epub 2024 Jan 3. Cell Rep. 2024. PMID: 38175754 Free PMC article.
LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses.
Ta HM, Roy D, Zhang K, Alban T, Juric I, Dong J, Parthasarathy PB, Patnaik S, Delaney E, Gilmour C, Zakeri A, Shukla N, Rupani A, Phoon YP, Liu C, Avril S, Gastman B, Chan T, Wang LL. Ta HM, et al. Sci Immunol. 2024 May 17;9(95):eadi7418. doi: 10.1126/sciimmunol.adi7418. Epub 2024 May 17. Sci Immunol. 2024. PMID: 38758807 Free PMC article.