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Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.
Nat Neurosci. 2021 Aug;24(8):1077-1088. doi: 10.1038/s41593-021-00859-9. Epub 2021 May 31.
Nat Neurosci. 2021.
PMID: 34059832
Free PMC article.
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
Tischbein M, Baron DM, Lin YC, Gall KV, Landers JE, Fallini C, Bosco DA.
Tischbein M, et al.
J Biol Chem. 2019 Jun 28;294(26):10194-10210. doi: 10.1074/jbc.RA118.005933. Epub 2019 May 15.
J Biol Chem. 2019.
PMID: 31092554
Free PMC article.
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ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.
Sama RR, Fallini C, Gatto R, McKeon JE, Song Y, Rotunno MS, Penaranda S, Abdurakhmanov I, Landers JE, Morfini G, Brady ST, Bosco DA.
Sama RR, et al.
Sci Rep. 2017 Mar 8;7(1):115. doi: 10.1038/s41598-017-00091-1.
Sci Rep. 2017.
PMID: 28273913
Free PMC article.
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