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tRNA dysregulation and disease.
Orellana EA, Siegal E, Gregory RI. Orellana EA, et al. Nat Rev Genet. 2022 Nov;23(11):651-664. doi: 10.1038/s41576-022-00501-9. Epub 2022 Jun 9. Nat Rev Genet. 2022. PMID: 35681060 Free PMC article. Review.
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. Orellana EA, et al. Mol Cell. 2021 Aug 19;81(16):3323-3338.e14. doi: 10.1016/j.molcel.2021.06.031. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352207 Free PMC article.
Structural basis of regulated m7G tRNA modification by METTL1-WDR4.
Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI. Li J, et al. Nature. 2023 Jan;613(7943):391-397. doi: 10.1038/s41586-022-05566-4. Epub 2023 Jan 4. Nature. 2023. PMID: 36599985 Free PMC article.
Exon junction complex shapes the m6A epitranscriptome.
Yang X, Triboulet R, Liu Q, Sendinc E, Gregory RI. Yang X, et al. Nat Commun. 2022 Dec 23;13(1):7904. doi: 10.1038/s41467-022-35643-1. Nat Commun. 2022. PMID: 36550132 Free PMC article.
METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing.
Chen H, Gu L, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y. Chen H, et al. Cell Res. 2020 Jun;30(6):544-547. doi: 10.1038/s41422-019-0270-4. Epub 2020 Jan 8. Cell Res. 2020. PMID: 31913360 Free PMC article. No abstract available.
LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy.
Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee AS, Dominguez D, Ting DT, Daley GQ. Missios P, et al. J Clin Invest. 2021 Nov 15;131(22):e145142. doi: 10.1172/JCI145142. J Clin Invest. 2021. PMID: 34779407 Free PMC article.
17 results