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A glycan gate controls opening of the SARS-CoV-2 spike protein.
Sztain T, Ahn SH, Bogetti AT, Casalino L, Goldsmith JA, Seitz E, McCool RS, Kearns FL, Acosta-Reyes F, Maji S, Mashayekhi G, McCammon JA, Ourmazd A, Frank J, McLellan JS, Chong LT, Amaro RE. Sztain T, et al. bioRxiv [Preprint]. 2021 May 17:2021.02.15.431212. doi: 10.1101/2021.02.15.431212. bioRxiv. 2021. Update in: Nat Chem. 2021 Oct;13(10):963-968. doi: 10.1038/s41557-021-00758-3 PMID: 33619492 Free PMC article. Updated. Preprint.
A glycan gate controls opening of the SARS-CoV-2 spike protein.
Sztain T, Ahn SH, Bogetti AT, Casalino L, Goldsmith JA, Seitz E, McCool RS, Kearns FL, Acosta-Reyes F, Maji S, Mashayekhi G, McCammon JA, Ourmazd A, Frank J, McLellan JS, Chong LT, Amaro RE. Sztain T, et al. Nat Chem. 2021 Oct;13(10):963-968. doi: 10.1038/s41557-021-00758-3. Epub 2021 Aug 19. Nat Chem. 2021. PMID: 34413500 Free PMC article.
RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis.
Shintaku J, Pernice WM, Eyaid W, Gc JB, Brown ZP, Juanola-Falgarona M, Torres-Torronteras J, Sommerville EW, Hellebrekers DM, Blakely EL, Donaldson A, van de Laar I, Leu CS, Marti R, Frank J, Tanji K, Koolen DA, Rodenburg RJ, Chinnery PF, Smeets HJM, Gorman GS, Bonnen PE, Taylor RW, Hirano M. Shintaku J, et al. J Clin Invest. 2022 Jul 1;132(13):e145660. doi: 10.1172/JCI145660. J Clin Invest. 2022. PMID: 35617047 Free PMC article.
How Dedicated Ribosomes Translate a Leaderless mRNA.
Acosta-Reyes FJ, Bhattacharjee S, Gottesman M, Frank J. Acosta-Reyes FJ, et al. J Mol Biol. 2024 Feb 15;436(4):168423. doi: 10.1016/j.jmb.2023.168423. Epub 2024 Jan 5. J Mol Biol. 2024. PMID: 38185325
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