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Thiazolidinediones: potential as therapeutics for psoriasis and perhaps other hyperproliferative skin disease.
Expert Opin Investig Drugs. 2006 Nov;15(11):1453-68. doi: 10.1517/13543784.15.11.1453.
Expert Opin Investig Drugs. 2006.
PMID: 17040203
Review.
Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation.
Ellis CN, Varani J, Fisher GJ, Zeigler ME, Pershadsingh HA, Benson SC, Chi Y, Kurtz TW.
Ellis CN, et al.
Arch Dermatol. 2000 May;136(5):609-16. doi: 10.1001/archderm.136.5.609.
Arch Dermatol. 2000.
PMID: 10815854
Clinical Trial.
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BP-1107 [{2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-amide]: a novel synthetic thiazolidinedione that inhibits epidermal hyperplasia in psoriatic skin-severe-combined immunodeficient mouse transplants after topical application.
Bhagavathula N, Nerusu KC, Reddy M, Ellis CN, Chittiboyina A, Avery M, Pershadsingh HA, Kurtz TW, Varani J.
Bhagavathula N, et al.
J Pharmacol Exp Ther. 2005 Dec;315(3):996-1004. doi: 10.1124/jpet.105.091066. Epub 2005 Aug 18.
J Pharmacol Exp Ther. 2005.
PMID: 16109743
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