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Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection.
Hassler L, Wysocki J, Ahrendsen JT, Ye M, Gelarden I, Nicolaescu V, Tomatsidou A, Gula H, Cianfarini C, Forster P, Khurram N, Singer BD, Randall G, Missiakas D, Henkin J, Batlle D. Hassler L, et al. Life Sci Alliance. 2023 Apr 11;6(7):e202301969. doi: 10.26508/lsa.202301969. Print 2023 Jul. Life Sci Alliance. 2023. PMID: 37041017 Free PMC article.
Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection.
Hassler L, Wysocki J, Ahrendsen JT, Ye M, Gelarden I, Nicolaescu V, Tomatsidou A, Gula H, Cianfarini C, Khurram N, Kanwar Y, Singer BD, Randall G, Missiakas D, Henkin J, Batlle D. Hassler L, et al. bioRxiv [Preprint]. 2022 Dec 6:2022.12.05.519032. doi: 10.1101/2022.12.05.519032. bioRxiv. 2022. PMID: 36523403 Free PMC article. Preprint.