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Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML.
Trinh BQ, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso MT, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A, Tenen DG. Trinh BQ, et al. Blood. 2021 Oct 14;138(15):1331-1344. doi: 10.1182/blood.2020007920. Blood. 2021. PMID: 33971010 Free PMC article.
Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.
van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB. van der Kouwe E, et al. Blood. 2021 Oct 14;138(15):1345-1358. doi: 10.1182/blood.2020008971. Blood. 2021. PMID: 34010414 Free PMC article.
Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.
Canesin G, Di Ruscio A, Li M, Ummarino S, Hedblom A, Choudhury R, Krzyzanowska A, Csizmadia E, Palominos M, Stiehm A, Ebralidze A, Chen SY, Bassal MA, Zhao P, Tolosano E, Hurley L, Bjartell A, Tenen DG, Wegiel B. Canesin G, et al. Cell Rep. 2020 Sep 22;32(12):108181. doi: 10.1016/j.celrep.2020.108181. Cell Rep. 2020. PMID: 32966797 Free PMC article.
Methylation Mesa define functional regulatory elements for targeted gene activation.
Liu YV, Suryatenggara J, Wong H, Jayasinghe MK, Tang JP, Tan HK, Kwon J, Zhou Q, Ummarino S, Ebralidze AK, Le MTN, Doench JG, Chai L, Benoukraf T, Hiwase D, Thomas D, Di Ruscio A, Tenen DG, Bassal MA. Liu YV, et al. Res Sq [Preprint]. 2024 Oct 16:rs.3.rs-4359582. doi: 10.21203/rs.3.rs-4359582/v1. Res Sq. 2024. PMID: 39483908 Free PMC article. Preprint.