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LRP1 is a master regulator of tau uptake and spread.
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. Rauch JN, et al. Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1. Nature. 2020. PMID: 32296178 Free PMC article.
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease.
Kim YS, Choi SH, Kim KY, Navia-Pelaez JM, Perkins GA, Choi S, Kim J, Nazarenkov N, Rissman RA, Ju WK, Ellisman MH, Miller YI. Kim YS, et al. bioRxiv [Preprint]. 2024 Mar 27:2024.02.16.580751. doi: 10.1101/2024.02.16.580751. bioRxiv. 2024. Update in: J Neuroinflammation. 2024 Sep 28;21(1):245. doi: 10.1186/s12974-024-03214-4 PMID: 38586011 Free PMC article. Updated. Preprint.
Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred.
Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton-Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, Anderson AG, Rodriguez-Nunez I, Roberts K, Dominantly Inherited Alzheimer Network, Absher D, Myers RM, Beecham GW, Reitz C, Rizzardi LF, Fernandez MV, Goate AM, Cruchaga C, Renton AE, Lopera F, Kosik KS. Cochran JN, et al. Alzheimers Dement. 2023 Sep;19(9):3835-3847. doi: 10.1002/alz.13021. Epub 2023 Mar 23. Alzheimers Dement. 2023. PMID: 36951251 Free PMC article.