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Page 1
Intercellular signaling by ectodomain shedding at the synapse.
Martín-de-Saavedra MD, Santos MD, Penzes P. Martín-de-Saavedra MD, et al. Trends Neurosci. 2022 Jun;45(6):483-498. doi: 10.1016/j.tins.2022.03.004. Epub 2022 Apr 13. Trends Neurosci. 2022. PMID: 35430102 Free PMC article. Review.
Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2.
Martín-de-Saavedra MD, Dos Santos M, Culotta L, Varea O, Spielman BP, Parnell E, Forrest MP, Gao R, Yoon S, McCoig E, Jalloul HA, Myczek K, Khalatyan N, Hall EA, Turk LS, Sanz-Clemente A, Comoletti D, Lichtenthaler SF, Burgdorf JS, Barbolina MV, Savas JN, Penzes P. Martín-de-Saavedra MD, et al. Neuron. 2022 Feb 16;110(4):627-643.e9. doi: 10.1016/j.neuron.2021.11.025. Epub 2021 Dec 17. Neuron. 2022. PMID: 34921780 Free PMC article.
CNTNAP2 is targeted to endosomes by the polarity protein PAR3.
Gao R, Pratt CP, Yoon S, Martin-de-Saavedra MD, Forrest MP, Penzes P. Gao R, et al. Eur J Neurosci. 2020 Feb;51(4):1074-1086. doi: 10.1111/ejn.14620. Epub 2019 Dec 2. Eur J Neurosci. 2020. PMID: 31730244 Free PMC article.
CNTNAP2 stabilizes interneuron dendritic arbors through CASK.
Gao R, Piguel NH, Melendez-Zaidi AE, Martin-de-Saavedra MD, Yoon S, Forrest MP, Myczek K, Zhang G, Russell TA, Csernansky JG, Surmeier DJ, Penzes P. Gao R, et al. Mol Psychiatry. 2018 Sep;23(9):1832-1850. doi: 10.1038/s41380-018-0027-3. Epub 2018 Apr 9. Mol Psychiatry. 2018. PMID: 29610457 Free PMC article.