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Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca2+, and activate NFAT and Akt signaling.
Robinson P, Sparrow AJ, Patel S, Malinowska M, Reilly SN, Zhang YH, Casadei B, Watkins H, Redwood C. Robinson P, et al. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H306-H319. doi: 10.1152/ajpheart.00272.2020. Epub 2020 Jul 3. Am J Physiol Heart Circ Physiol. 2020. PMID: 32618513 Free PMC article.