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Distinct chemical environments in biomolecular condensates.
Kilgore HR, Mikhael PG, Overholt KJ, Boija A, Hannett NM, Van Dongen C, Lee TI, Chang YT, Barzilay R, Young RA. Kilgore HR, et al. Nat Chem Biol. 2024 Mar;20(3):291-301. doi: 10.1038/s41589-023-01432-0. Epub 2023 Sep 28. Nat Chem Biol. 2024. PMID: 37770698
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.
Dall'Agnese A, Platt JM, Zheng MM, Friesen M, Dall'Agnese G, Blaise AM, Spinelli JB, Henninger JE, Tevonian EN, Hannett NM, Lazaris C, Drescher HK, Bartsch LM, Kilgore HR, Jaenisch R, Griffith LG, Cisse II, Jeppesen JF, Lee TI, Young RA. Dall'Agnese A, et al. Nat Commun. 2022 Dec 6;13(1):7522. doi: 10.1038/s41467-022-35176-7. Nat Commun. 2022. PMID: 36473871 Free PMC article.
Regulatory architecture of housekeeping genes is driven by promoter assemblies.
Dejosez M, Dall'Agnese A, Ramamoorthy M, Platt J, Yin X, Hogan M, Brosh R, Weintraub AS, Hnisz D, Abraham BJ, Young RA, Zwaka TP. Dejosez M, et al. Cell Rep. 2023 May 30;42(5):112505. doi: 10.1016/j.celrep.2023.112505. Epub 2023 May 12. Cell Rep. 2023. PMID: 37182209 Free PMC article.