Abstract
Plants of the Amaryllidaceae family are promising therapeutic tools for human diseases and have been used as alternative medicines. The specific secondary metabolites of this plant family, called Amaryllidaceae alkaloids (AA), have attracted considerable attention due to their interesting pharmacological activities. One of them, galantamine, is already used in the therapy of Alzheimer's disease as a long acting, selective, reversible inhibitor of acetylcholinesterase. One group of AA is the montanine-type, such as montanine, pancracine and others, which share a 5,11-methanomorphanthridine core. So far, only 14 montanine-type alkaloids have been isolated. Compared with other structural-types of AA, montanine-type alkaloids are predominantly present in plants in low concentrations, but some of them display promising biological properties, especially in vitro cytotoxic activity against different cancerous cell lines. The present review aims to summarize comprehensively the research that has been published on the Amaryllidaceae alkaloids of montanine-type.
Keywords:
Amaryllidaceae; alkaloids; biological activity; derivatives; montanine; montanine-type; pancracine.
MeSH terms
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Amaryllidaceae / chemistry*
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Amaryllidaceae / metabolism
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Amaryllidaceae Alkaloids / chemistry*
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Amaryllidaceae Alkaloids / isolation & purification
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Amaryllidaceae Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antiprotozoal Agents / chemistry*
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology
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Cell Line, Tumor
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Cholinesterase Inhibitors / chemistry*
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / pharmacology
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Galantamine / chemistry
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Galantamine / isolation & purification
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Galantamine / pharmacology
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Humans
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Inhibitory Concentration 50
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification
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Isoquinolines / pharmacology
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Nootropic Agents / chemistry*
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Nootropic Agents / isolation & purification
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Nootropic Agents / pharmacology
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Phenanthridines / chemistry
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Phenanthridines / isolation & purification
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Phenanthridines / pharmacology
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Plant Extracts / chemistry
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Secondary Metabolism
Substances
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Amaryllidaceae Alkaloids
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Antineoplastic Agents, Phytogenic
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Antiprotozoal Agents
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Cholinesterase Inhibitors
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Heterocyclic Compounds, 4 or More Rings
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Isoquinolines
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Nootropic Agents
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Phenanthridines
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Plant Extracts
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montanine
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pancracine
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Galantamine
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hemanthamine