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Transgenic mice for in vivo epigenome editing with CRISPR-based systems.
Gemberling MP, Siklenka K, Rodriguez E, Tonn-Eisinger KR, Barrera A, Liu F, Kantor A, Li L, Cigliola V, Hazlett MF, Williams CA, Bartelt LC, Madigan VJ, Bodle JC, Daniels H, Rouse DC, Hilton IB, Asokan A, Ciofani M, Poss KD, Reddy TE, West AE, Gersbach CA. Gemberling MP, et al. Nat Methods. 2021 Aug;18(8):965-974. doi: 10.1038/s41592-021-01207-2. Epub 2021 Aug 2. Nat Methods. 2021. PMID: 34341582 Free PMC article.
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. Yan R, et al. Cell Stem Cell. 2023 Jan 5;30(1):96-111.e6. doi: 10.1016/j.stem.2022.11.012. Epub 2022 Dec 13. Cell Stem Cell. 2023. PMID: 36516837 Free PMC article.
The once and future gene therapy.
Bulaklak K, Gersbach CA. Bulaklak K, et al. Nat Commun. 2020 Nov 16;11(1):5820. doi: 10.1038/s41467-020-19505-2. Nat Commun. 2020. PMID: 33199717 Free PMC article.
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models.
Hakim CH, Kumar SRP, Pérez-López DO, Wasala NB, Zhang D, Yue Y, Teixeira J, Pan X, Zhang K, Million ED, Nelson CE, Metzger S, Han J, Louderman JA, Schmidt F, Feng F, Grimm D, Smith BF, Yao G, Yang NN, Gersbach CA, Chen SJ, Herzog RW, Duan D. Hakim CH, et al. Nat Commun. 2021 Nov 24;12(1):6769. doi: 10.1038/s41467-021-26830-7. Nat Commun. 2021. PMID: 34819506 Free PMC article.
Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators.
Beyersdorf JP, Bawage S, Iglesias N, Peck HE, Hobbs RA, Wroe JA, Zurla C, Gersbach CA, Santangelo PJ. Beyersdorf JP, et al. ACS Nano. 2022 Apr 26;16(4):5660-5671. doi: 10.1021/acsnano.1c10631. Epub 2022 Mar 31. ACS Nano. 2022. PMID: 35357116 Free PMC article.
15 results