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274 results

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Page 1
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Stockwell BR, et al. Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Cell. 2017. PMID: 28985560 Free PMC article. Review.
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M. Doll S, et al. Nat Chem Biol. 2017 Jan;13(1):91-98. doi: 10.1038/nchembio.2239. Epub 2016 Nov 14. Nat Chem Biol. 2017. PMID: 27842070 Free PMC article.
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H. Kagan VE, et al. Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. Epub 2016 Nov 14. Nat Chem Biol. 2017. PMID: 27842066 Free PMC article.
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.
Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE. Wenzel SE, et al. Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044. Cell. 2017. PMID: 29053969 Free PMC article.
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.
Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE. Kapralov AA, et al. Nat Chem Biol. 2020 Mar;16(3):278-290. doi: 10.1038/s41589-019-0462-8. Epub 2020 Feb 17. Nat Chem Biol. 2020. PMID: 32080625 Free PMC article.
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation.
Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, Peguero-Pereira E, Fomich MA, Daniels JD, Bekish AV, Shmanai VV, Kagan VE, Mahal LK, Woerpel KA, Stockwell BR. Gaschler MM, et al. Nat Chem Biol. 2018 May;14(5):507-515. doi: 10.1038/s41589-018-0031-6. Epub 2018 Apr 2. Nat Chem Biol. 2018. PMID: 29610484 Free PMC article.
Dehydroepiandrosterone and Bone.
Zhou S, Glowacki J. Zhou S, et al. Vitam Horm. 2018;108:251-271. doi: 10.1016/bs.vh.2018.01.005. Epub 2018 Feb 24. Vitam Horm. 2018. PMID: 30029729
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.
Beatty A, Singh T, Tyurina YY, Tyurin VA, Samovich S, Nicolas E, Maslar K, Zhou Y, Cai KQ, Tan Y, Doll S, Conrad M, Subramanian A, Bayır H, Kagan VE, Rennefahrt U, Peterson JR. Beatty A, et al. Nat Commun. 2021 Apr 14;12(1):2244. doi: 10.1038/s41467-021-22471-y. Nat Commun. 2021. PMID: 33854057 Free PMC article.
274 results