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Targeting RNA structures with small molecules.
Childs-Disney JL, Yang X, Gibaut QMR, Tong Y, Batey RT, Disney MD. Childs-Disney JL, et al. Nat Rev Drug Discov. 2022 Oct;21(10):736-762. doi: 10.1038/s41573-022-00521-4. Epub 2022 Aug 8. Nat Rev Drug Discov. 2022. PMID: 35941229 Free PMC article. Review.
Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
Tong Y, Zhang P, Yang X, Liu X, Zhang J, Grudniewska M, Jung I, Abegg D, Liu J, Childs-Disney JL, Gibaut QMR, Haniff HS, Adibekian A, Mouradian MM, Disney MD. Tong Y, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306682120. doi: 10.1073/pnas.2306682120. Epub 2024 Jan 5. Proc Natl Acad Sci U S A. 2024. PMID: 38181056 Free PMC article.
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