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Page 1
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.
Tzelepis K, Koike-Yusa H, De Braekeleer E, Li Y, Metzakopian E, Dovey OM, Mupo A, Grinkevich V, Li M, Mazan M, Gozdecka M, Ohnishi S, Cooper J, Patel M, McKerrell T, Chen B, Domingues AF, Gallipoli P, Teichmann S, Ponstingl H, McDermott U, Saez-Rodriguez J, Huntly BJP, Iorio F, Pina C, Vassiliou GS, Yusa K. Tzelepis K, et al. Cell Rep. 2016 Oct 18;17(4):1193-1205. doi: 10.1016/j.celrep.2016.09.079. Cell Rep. 2016. PMID: 27760321 Free PMC article.
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.
Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T. Barbieri I, et al. Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27. Nature. 2017. PMID: 29186125 Free PMC article.
Aging as a driver of leukemogenesis.
McKerrell T, Vassiliou GS. McKerrell T, et al. Sci Transl Med. 2015 Sep 23;7(306):306fs38. doi: 10.1126/scitranslmed.aac4428. Epub 2015 Sep 23. Sci Transl Med. 2015. PMID: 26400908 Free PMC article.
Clonal haematopoiesis is not prevalent in survivors of childhood cancer.
Collord G, Park N, Podestà M, Dagnino M, Cilloni D, Jones D, Varela I, Frassoni F, Vassiliou GS. Collord G, et al. Br J Haematol. 2018 May;181(4):537-539. doi: 10.1111/bjh.14630. Epub 2017 Apr 3. Br J Haematol. 2018. PMID: 28369776 Free PMC article. Clinical Trial. No abstract available.
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas.
Noorani I, de la Rosa J, Choi YH, Strong A, Ponstingl H, Vijayabaskar MS, Lee J, Lee E, Richard-Londt A, Friedrich M, Furlanetto F, Fuente R, Banerjee R, Yang F, Law F, Watts C, Rad R, Vassiliou G, Kim JK, Santarius T, Brandner S, Bradley A. Noorani I, et al. Genome Biol. 2020 Jul 30;21(1):181. doi: 10.1186/s13059-020-02092-2. Genome Biol. 2020. PMID: 32727536 Free PMC article.