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Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.
Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z; Accelerating Medicines Partnership® RA/SLE Program and Network; Brenner MB, McDavid A, Donlin LT, Wei K, Price AL, Raychaudhuri S. Sakaue S, et al. Nat Genet. 2024 Apr;56(4):615-626. doi: 10.1038/s41588-024-01682-1. Epub 2024 Apr 9. Nat Genet. 2024. PMID: 38594305 Free PMC article.
Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability.
Gupta A, Weinand K, Nathan A, Sakaue S, Zhang MJ; Accelerating Medicines Partnership RA/SLE Program and Network; Donlin L, Wei K, Price AL, Amariuta T, Raychaudhuri S. Gupta A, et al. Nat Genet. 2023 Dec;55(12):2200-2210. doi: 10.1038/s41588-023-01577-7. Epub 2023 Nov 30. Nat Genet. 2023. PMID: 38036783 Free PMC article.