Abstract
Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Astrocytoma / pathology
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Astrocytoma / physiopathology
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Brain / pathology*
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Brain / physiopathology
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Brain Neoplasms / classification
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Brain Neoplasms / pathology*
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Brain Neoplasms / physiopathology
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Cell Proliferation
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Disease Progression
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Female
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Glioma / classification
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Glioma / pathology*
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Glioma / physiopathology
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Gonadal Steroid Hormones / metabolism
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Growth Hormone / metabolism
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Humans
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Magnetic Resonance Imaging
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Neoplasm Invasiveness / pathology*
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Oligodendroglioma / pathology
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Oligodendroglioma / physiopathology
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Placenta / metabolism
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Pregnancy
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Pregnancy Complications, Neoplastic / pathology*
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Pregnancy Complications, Neoplastic / physiopathology
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Seizures / etiology
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Seizures / physiopathology
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World Health Organization
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Young Adult
Substances
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Gonadal Steroid Hormones
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Growth Hormone