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Page 1
Showing results for lipids a
Search for Lipi SA instead (3 results)
ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease.
Lanfranco MF, Ng CA, Rebeck GW. Lanfranco MF, et al. Int J Mol Sci. 2020 Sep 1;21(17):6336. doi: 10.3390/ijms21176336. Int J Mol Sci. 2020. PMID: 32882843 Free PMC article. Review.
Here we highlight the importance of lipidated apoE as well as the APOE-lipidation targeted therapeutic approaches that have the potential to correct or prevent neurodegeneration. ...Overall, there is great potential to improve the lipidated state of apoE with …
Here we highlight the importance of lipidated apoE as well as the APOE-lipidation targeted therapeutic approaches that have th …
Cellular lipidomics.
van Meer G. van Meer G. EMBO J. 2005 Sep 21;24(18):3159-65. doi: 10.1038/sj.emboj.7600798. Epub 2005 Sep 1. EMBO J. 2005. PMID: 16138081 Free PMC article. Review.
To incorporate function, cellular lipidomics must not only determine which lipids are present but also the concentration of each lipid at each specific intracellular location in time and the lipid's interaction partners. Moreover, cellular lipidomics m …
To incorporate function, cellular lipidomics must not only determine which lipids are present but also the concentration of each l …
LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.
Omrane M, Ben M'Barek K, Santinho A, Nguyen N, Nag S, Melia TJ, Thiam AR. Omrane M, et al. Dev Cell. 2023 Jul 24;58(14):1266-1281.e7. doi: 10.1016/j.devcel.2023.05.009. Epub 2023 Jun 13. Dev Cell. 2023. PMID: 37315562 Free PMC article.
Lipid droplets (LDs) store lipids that can be utilized during times of scarcity via autophagic and lysosomal pathways, but how LDs and autophagosomes interact remained unclear. ...We observed that LC3B-lipidated LDs were consistently in close proximity to col …
Lipid droplets (LDs) store lipids that can be utilized during times of scarcity via autophagic and lysosomal pathways, but how …
From the banal to the bizarre: unravelling immune recognition and response to microbial lipids.
Burchill L, Williams SJ. Burchill L, et al. Chem Commun (Camb). 2022 Jan 20;58(7):925-940. doi: 10.1039/d1cc06003a. Chem Commun (Camb). 2022. PMID: 34989357 Review.
Microbes produce a rich array of lipidic species that through their location in the cell wall and ability to mingle with host lipids represent a privileged class of immune-active molecules. Lipid-sensing immunity recognizes microbial lipids from pathog …
Microbes produce a rich array of lipidic species that through their location in the cell wall and ability to mingle with host lipi …
Peptide Lipidation - A Synthetic Strategy to Afford Peptide Based Therapeutics.
Kowalczyk R, Harris PWR, Williams GM, Yang SH, Brimble MA. Kowalczyk R, et al. Adv Exp Med Biol. 2017;1030:185-227. doi: 10.1007/978-3-319-66095-0_9. Adv Exp Med Biol. 2017. PMID: 29081055 Free PMC article. Review.
Peptide and protein aberrant lipidation patterns are often involved in many diseases including cancer and neurological disorders. ...Self-adjuvanting peptide-based vaccines commonly utilise the powerful TLR2 agonist Pam(n)Cys lipid to stimulate adjuvant activity. Th …
Peptide and protein aberrant lipidation patterns are often involved in many diseases including cancer and neurological disorders. ... …
Amino acid-containing membrane lipids in bacteria.
Geiger O, González-Silva N, López-Lara IM, Sohlenkamp C. Geiger O, et al. Prog Lipid Res. 2010 Jan;49(1):46-60. doi: 10.1016/j.plipres.2009.08.002. Epub 2009 Aug 22. Prog Lipid Res. 2010. PMID: 19703488 Review.
In few bacteria, diacylglycerol-derived lipids can be substituted with lysine or homoserine. Acyl-oxyacyl lipids in which the lipidic part is amide-linked to the alpha-amino group of an amino acid are widely distributed among bacteria and ornithine-containing …
In few bacteria, diacylglycerol-derived lipids can be substituted with lysine or homoserine. Acyl-oxyacyl lipids in which the …
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication.
Yuan Y, Li P, Li J, Zhao Q, Chang Y, He X. Yuan Y, et al. Signal Transduct Target Ther. 2024 Mar 15;9(1):60. doi: 10.1038/s41392-024-01759-7. Signal Transduct Target Ther. 2024. PMID: 38485938 Free PMC article. Review.
Decades of dedicated research have driven the development of a wide range of drugs targeting protein lipidation, and several agents have been developed and tested in preclinical and clinical studies, some of which, such as asciminib and lonafarnib are FDA-approved for ther …
Decades of dedicated research have driven the development of a wide range of drugs targeting protein lipidation, and several agents h …
A review of lipidation in the development of advanced protein and peptide therapeutics.
Menacho-Melgar R, Decker JS, Hennigan JN, Lynch MD. Menacho-Melgar R, et al. J Control Release. 2019 Feb 10;295:1-12. doi: 10.1016/j.jconrel.2018.12.032. Epub 2018 Dec 21. J Control Release. 2019. PMID: 30579981 Free PMC article. Review.
Despite its great potential, lipidation remains an underutilized strategy in the clinical translation of lead biologics. We review how lipidation can overcome common challenges in biologics development as well as highlight gaps in our understanding of the effect of …
Despite its great potential, lipidation remains an underutilized strategy in the clinical translation of lead biologics. We review ho …
Cationic lipids from multi-component Passerini reaction for non-viral gene delivery: A structure-activity relationship study.
Chen JJ, Guo Y, Wang R, Yang HZ, Yu XQ, Zhang J. Chen JJ, et al. Bioorg Med Chem. 2024 Feb 15;100:117635. doi: 10.1016/j.bmc.2024.117635. Epub 2024 Feb 7. Bioorg Med Chem. 2024. PMID: 38340641
Although many types of cationic lipids have been developed as efficient gene vectors, the construction of lipid molecules with simple procedures remains challenging. ...It was found that although both of the two series of lipids could form lipid nanopa …
Although many types of cationic lipids have been developed as efficient gene vectors, the construction of lipid molecules with …
1,689,114 results
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