Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2021 2
2023 2
2024 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

6 results

Results by year

Filters applied: . Clear all
Page 1
National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research.
Mendelson AA, Lansdell C, Fox-Robichaud AE, Liaw P, Arora J, Cailhier JF, Cepinskas G, Charbonney E, Dos Santos C, Dwivedi D, Ellis CG, Fergusson D, Fiest K, Gill SE, Hendrick K, Hunniford VT, Kowalewska PM, Krewulak K, Lehmann C, Macala K, Marshall JC, Mawdsley L, McDonald B, McDonald E, Medeiros SK, Muniz VS, Osuchowski M, Presseau J, Sharma N, Sohrabipour S, Sunohara-Neilson J, Vázquez-Grande G, Veldhuizen RAW, Welsh D, Winston BW, Zarychanski R, Zhang H, Zhou J, Lalu MM; Sepsis Canada’s National Preclinical Sepsis Platform. Mendelson AA, et al. Intensive Care Med Exp. 2021 Mar 19;9(1):14. doi: 10.1186/s40635-020-00366-4. Intensive Care Med Exp. 2021. PMID: 33738642 Free PMC article.
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. ...To this end, we organized the first meeting of the National Preclinical Sepsis Platform …
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into ro …
Sex- and Gender-Dependent Differences in Clinical and Preclinical Sepsis.
Zhang MQ, Macala KF, Fox-Robichaud A, Mendelson AA, Lalu MM; Sepsis Canada National Preclinical Sepsis Platform. Zhang MQ, et al. Shock. 2021 Aug 1;56(2):178-187. doi: 10.1097/SHK.0000000000001717. Shock. 2021. PMID: 33399356 Review.
This may be of particular importance in sepsis, given the potential contribution of sex bias in the failures of translational sepsis research in adults and neonates. Clinical evidence of sex-dependent differences in sepsis is equivocal. Since clinical studies …
This may be of particular importance in sepsis, given the potential contribution of sex bias in the failures of translational seps …
Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions.
Sharma N, Chwastek D, Dwivedi DJ, Schlechte J, Yu IL, McDonald B, Arora J, Cani E, Eng M, Engelberts D, Kuhar E, Medeiros SK, Bourque SL, Cepinskas G, Gill SE, Jahandideh F, Macala KF, Panahi S, Pape C, Sontag D, Sunohara-Neilson J, Fergusson DA, Fox-Robichaud AE, Liaw PC, Lalu MM, Mendelson AA; National Preclinical Sepsis Platform, Sepsis Canada. Sharma N, et al. Intensive Care Med Exp. 2023 Jul 17;11(1):45. doi: 10.1186/s40635-023-00533-3. Intensive Care Med Exp. 2023. PMID: 37460911 Free PMC article.
BACKGROUND: Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis P …
BACKGROUND: Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer …
Sepsis and obesity: a scoping review of diet-induced obesity murine models.
Eng M, Suthaaharan K, Newton L, Sheikh F, Fox-Robichaud A; National Preclinical Sepsis Platform, Sepsis Canada. Eng M, et al. Intensive Care Med Exp. 2024 Feb 23;12(1):15. doi: 10.1186/s40635-024-00603-0. Intensive Care Med Exp. 2024. PMID: 38388878 Free PMC article. Review.
BACKGROUND: Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the "obesity paradox". ...
BACKGROUND: Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability t …
Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol.
Zhang M, Fergusson DA, Sharma R, Khoo C, Mendelson AA, McDonald B, Macala KF, Sharma N, Gill SE, Fiest KM, Lehmann C, Shorr R, Jahandideh F, Bourque SL, Liaw PC, Fox-Robichaud A, Lalu MM; Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform. Zhang M, et al. Syst Rev. 2023 Mar 21;12(1):50. doi: 10.1186/s13643-023-02189-2. Syst Rev. 2023. PMID: 36945012 Free PMC article.
METHODS: MEDLINE and Embase will be searched (2011-present) to identify preclinical studies of sepsis in which any intervention was administered and sex-stratified data reported. ...DISCUSSION: Our systematic review will summarize the current state of knowledge on s …
METHODS: MEDLINE and Embase will be searched (2011-present) to identify preclinical studies of sepsis in which any interventio …