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Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19.
Grant RA, Poor TA, Sichizya L, Diaz E, Bailey JI, Soni S, Senkow KJ, Pérez-Leonor XG, Abdala-Valencia H, Lu Z, Donnelly HK, Simons LM, Ozer EA, Tighe RM, Lomasney JW, Wunderink RG, Singer BD, Misharin AV, Budinger GRS; Northwestern University Successful Clinical Response In Pneumonia Therapy (NU SCRIPT) Investigators. Grant RA, et al. Among authors: senkow kj. JCI Insight. 2024 Mar 19;9(8):e178859. doi: 10.1172/jci.insight.178859. JCI Insight. 2024. PMID: 38502186 Free PMC article.
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia.
Markov NS, Ren Z, Senkow KJ, Grant RA, Gao CA, Malsin ES, Sichizya L, Kihshen H, Helmin KA, Jovisic M, Arnold JM, Pérez-Leonor XG, Abdala-Valencia H, Swaminathan S, Nwaezeapu J, Kang M, Rasmussen L, Ozer EA, Lorenzo-Redondo R, Hultquist JF, Simons LM, Rios-Guzman E, Misharin AV, Wunderink RG, Budinger GRS, Singer BD, Morales-Nebreda L; NU SCRIPT Study Investigators. Markov NS, et al. Among authors: senkow kj. Nat Immunol. 2024 Sep;25(9):1607-1622. doi: 10.1038/s41590-024-01914-w. Epub 2024 Aug 13. Nat Immunol. 2024. PMID: 39138384
Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.
Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S, Qi C, Pawlowski AE, Neely MN, Misharin AV, Wunderink RG, Rhodes NJ; NU SCRIPT Study investigators. Rohani R, et al. J Antimicrob Chemother. 2022 Oct 28;77(11):2956-2959. doi: 10.1093/jac/dkac245. J Antimicrob Chemother. 2022. PMID: 35869779 Free PMC article.
Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.
Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S, Grant RA, Abdala-Valencia H, Mylvaganam RJ, Ludwig A, Miller J, Cumming RI, Tighe RM, Gowdy KM, Kalhan R, Jain M, Bharat A, Kurihara C, San Jose Estepar R, San Jose Estepar R, Washko GR, Shilatifard A, Sznajder JI, Ridge KM, Budinger GRS, Braun R, Misharin AV, Sala MA. Bailey JI, et al. Among authors: senkow kj. Nat Immunol. 2024 Nov;25(11):2097-2109. doi: 10.1038/s41590-024-01975-x. Epub 2024 Oct 4. Nat Immunol. 2024. PMID: 39367123 Free PMC article.
A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia.
Markov NS, Ren Z, Senkow KJ, Grant RA, Gao CA, Malsin ES, Sichizya L, Kihshen H, Helmin KA, Jovisic M, Arnold JM, Pérez-Leonor XG, Abdala-Valencia H, Swaminathan S, Nwaezeapu J, Kang M, Rasmussen L, Ozer EA, Lorenzo-Redondo R, Hultquist JF, Simons LM, Rios-Guzman E, Misharin AV, Wunderink RG, Budinger GRS, Singer BD, Morales-Nebreda L; NU SCRIPT Study Investigators. Markov NS, et al. Among authors: senkow kj. bioRxiv [Preprint]. 2023 Dec 14:2023.12.13.571479. doi: 10.1101/2023.12.13.571479. bioRxiv. 2023. Update in: Nat Immunol. 2024 Sep;25(9):1607-1622. doi: 10.1038/s41590-024-01914-w PMID: 38168346 Free PMC article. Updated. Preprint.
Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19.
Grant RA, Poor TA, Sichizya L, Diaz E, Bailey JI, Soni S, Senkow KJ, Pérez-Leonor XG, Abdala-Valencia H, Lu Z, Donnelly HK, Tighe RM, Lomasney JW, Wunderink RG, Singer BD, Misharin AV, Budinger GS. Grant RA, et al. Among authors: senkow kj. bioRxiv [Preprint]. 2023 Jul 28:2023.07.28.550765. doi: 10.1101/2023.07.28.550765. bioRxiv. 2023. Update in: JCI Insight. 2024 Mar 19;9(8):e178859. doi: 10.1172/jci.insight.178859 PMID: 37546860 Free PMC article. Updated. Preprint.