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Year Number of Results
1971 1
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1994 2
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1999 3
2000 2
2001 3
2002 2
2003 4
2004 4
2005 14
2006 6
2007 5
2008 10
2009 8
2010 11
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226 results

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Page 1
The mycobacterial cell envelope - a moving target.
Dulberger CL, Rubin EJ, Boutte CC. Dulberger CL, et al. Nat Rev Microbiol. 2020 Jan;18(1):47-59. doi: 10.1038/s41579-019-0273-7. Epub 2019 Nov 14. Nat Rev Microbiol. 2020. PMID: 31728063 Review.
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and immunomodulatory cell envelope. ...
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and immunomodulatory cell envelope. ...
Tuberculosis.
Bloom BR, Atun R, Cohen T, Dye C, Fraser H, Gomez GB, Knight G, Murray M, Nardell E, Rubin E, Salomon J, Vassall A, Volchenkov G, White R, Wilson D, Yadav P. Bloom BR, et al. In: Holmes KK, Bertozzi S, Bloom BR, Jha P, editors. Major Infectious Diseases. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Nov 3. Chapter 11. In: Holmes KK, Bertozzi S, Bloom BR, Jha P, editors. Major Infectious Diseases. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Nov 3. Chapter 11. PMID: 30212088 Free Books & Documents. Review.
Tuberculosis is an infectious bacterial disease caused by Mycobacterium tuberculosis (Mtb), which is transmitted between humans through the respiratory route and most commonly affects the lungs, but can damage any tissue. ...
Tuberculosis is an infectious bacterial disease caused by Mycobacterium tuberculosis (Mtb), which is transmitted between humans throu …
Tuberculosis treatment failure associated with evolution of antibiotic resilience.
Liu Q, Zhu J, Dulberger CL, Stanley S, Wilson S, Chung ES, Wang X, Culviner P, Liu YJ, Hicks ND, Babunovic GH, Giffen SR, Aldridge BB, Garner EC, Rubin EJ, Chao MC, Fortune SM. Liu Q, et al. Science. 2022 Dec 9;378(6624):1111-1118. doi: 10.1126/science.abq2787. Epub 2022 Dec 8. Science. 2022. PMID: 36480634 Free PMC article.
The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis (Mtb)clinical isolates has identified an essential transcriptional regulator, Rv1830, herein cal …
The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis …
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.
DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. DeJesus MA, et al. mBio. 2017 Jan 17;8(1):e02133-16. doi: 10.1128/mBio.02133-16. mBio. 2017. PMID: 28096490 Free PMC article.
We sought to overcome this limitation by creating a completely saturated transposon library in Mycobacterium tuberculosis In assessing the composition of this highly saturated library by deep sequencing, we discovered that a previously unknown sequence bias of the Himar1 e …
We sought to overcome this limitation by creating a completely saturated transposon library in Mycobacterium tuberculosis In assessin …
The Dream of a Mycobacterium.
Baranowski C, Rego EH, Rubin EJ. Baranowski C, et al. Microbiol Spectr. 2019 Mar;7(2):10.1128/microbiolspec.gpp3-0008-2018. doi: 10.1128/microbiolspec.GPP3-0008-2018. Microbiol Spectr. 2019. PMID: 31025625 Free PMC article. Review.
How do mycobacteria divide? Cell division has been studied extensively in the model rod-shaped bacteria Escherichia coli and Bacillus subtilis, but much less is understood about cell division in mycobacteria, a genus that includes the major human pathogens M. tuberc …
How do mycobacteria divide? Cell division has been studied extensively in the model rod-shaped bacteria Escherichia coli and Bacillus …
A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth.
Tomasi FG, Kimura S, Rubin EJ, Waldor MK. Tomasi FG, et al. Elife. 2023 Sep 27;12:RP87146. doi: 10.7554/eLife.87146. Elife. 2023. PMID: 37755167 Free PMC article.
Although tRNA modification is universal in all kingdoms of life, profiles of modifications, their functions, and physiological roles have not been elucidated in most organisms including the human pathogen, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculos …
Although tRNA modification is universal in all kingdoms of life, profiles of modifications, their functions, and physiological roles have no …
Mycobacterial Growth.
Uhía I, Williams KJ, Shahrezaei V, Robertson BD. Uhía I, et al. Cold Spring Harb Perspect Med. 2015 May 8;5(10):a021097. doi: 10.1101/cshperspect.a021097. Cold Spring Harb Perspect Med. 2015. PMID: 25957314 Free PMC article. Review.
In this work, we review progress made in understanding the molecular underpinnings of growth and division in mycobacteria, concentrating on work published since the last comprehensive review ( Hett and Rubin 2008). We have focused on exciting work making use of new …
In this work, we review progress made in understanding the molecular underpinnings of growth and division in mycobacteria, concentrat …
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.
Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Rock JM, et al. Nat Microbiol. 2017 Feb 6;2:16274. doi: 10.1038/nmicrobiol.2016.274. Nat Microbiol. 2017. PMID: 28165460 Free PMC article.
The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineer …
The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time req …
Genes required for mycobacterial growth defined by high density mutagenesis.
Sassetti CM, Boyd DH, Rubin EJ. Sassetti CM, et al. Mol Microbiol. 2003 Apr;48(1):77-84. doi: 10.1046/j.1365-2958.2003.03425.x. Mol Microbiol. 2003. PMID: 12657046 Free article.
Here, we describe the use of transposon site hybridization (TraSH) to comprehensively identify the genes required by the causative agent, Mycobacterium tuberculosis, for optimal growth. These genes include those that can be assigned to essential pathways as well as many of …
Here, we describe the use of transposon site hybridization (TraSH) to comprehensively identify the genes required by the causative agent, …
226 results